The impact of adjuvant treatment with external beam radiotherapy and vaginal brachytherapy on health-related quality of life in patients with early-stage endometrioid endometrial carcinoma — initial results of a prospective study

Objectives: Our study evaluates the impact of adjuvant treatment with external beam radiotherapy (EBRT) combined vaginal high-dose-rate brachytherapy (HDR BT) on health-related quality life (HRQL) in patients early-stage endometrioid endometrial carcinoma. Material and methods: We assessed HRQL based EORTC QLQ-C30 questionnaire, cancer specific module — QLQ-EN24. From March 2019 to April 2020 we enrolled 20 carcinoma, qualified for after hysterectomy. compared scores measured questionnaires at beginning end treatment. Results: There was a statistically significant decrease mean global health status/quality according scale, from 62.25 ± 13.12 55.85 14.68 (p = 0.047). The appetite loss score higher onset as its value EBRT, 19.9 27.33 vs 11.6 19.52 0.043). Similarly constipation score, which 29.85 30.40 0.013). diarrhoea symptom scale increased 16.55 20.16 56.75 36.10 0.001). In QLQ-EN24 scales, gastrointestinal symptoms were treatment, (with 26.45 22.76) 14.30 16.52 EBRT 0.003). Conclusions: Patients who receive have decreased during reporting more serious symptoms. potential risk treatment-related toxicity should be taken into account planning process order minimize deterioration HRQL.